During the menstrual cycle, the endometrium cycles through a proliferative phase (growth phase) and secretory phase in response to hormones (estrogen and progesterone) made and released by the ovaries. Frequent, unpredictable periods whose lengths and heaviness vary. focal mucinous metaplasia. The proliferative and hyperplastic endometrium was commonly reported. Hormonal imbalances: Hormonal imbalances, such as decreased levels of estrogen and progesterone, can contribute to the endometrium. Weakly proliferative endometrium is a normal finding in some women, but it can also be a sign of cancer or other problems. Decidualized stromal cells are derived from the fibroblast-like cells within the endometrium, which maintain their progesterone receptors in the presence of progesterone. Endometrial hyperplasia (EH) is a pre-cancerous, non-physiological, non-invasive proliferation of the endometrium that results in increased volume of endometrial tissue with alterations of glandular architecture (shape and size) and endometrial gland to stroma ratio of greater than 1:1 [5,6]. General Surgeon. The endometrial tissue is a sensitive target for steroid sex hormones and is able to modify its structural characteristics with promptness and versatility. How is proliferative endometrium treated? Endometrial hyperplasia treatment The most. Normal : It's benign tissue that shows estrogen effect (proliferative endometrium), cell changes that are benign (ciliated metaplasia) & no precancerous or can. endometrium, biopsy: - consistent with menstrual phase endometrium: -- weakly proliferative endometrial glands with neutrophils and apoptosis. Dr. 2 Proliferative Endometrium4,572 satisfied customers. 00 became effective on October 1, 2023. The proliferative endometrium is what is shed from the uterus when a woman has her cycle. Study design: This is a retrospective cohort study of 1808 women aged 55 years. Some, but not all features of atrophy may also be seen in. 11. Ed Friedlander and 4 doctors agree. (47). Biopsy results may show cell changes linked to hormone levels, or abnormal tissues, such as fibroids or polyps. What does this mean? endometrium, biopsy: disordered proliferative endometrium with associated simple (cystic) hyperplasia. Proliferation is a noncancerous change in the endometrium. Two thirds of proliferative endometrium with breakdown showed plasma cells (19% grade 1, 39% grade 2, 10 % grade 3). Glandular tissue usually inactive and of basalis or proliferative type endometrium, but one fourth is functional; hemosiderin is generally absent (Am J Obstet Gynecol 1971;110:275)Endometrial hyperplasia (EH) is categorized into two groups: EH without atypia and EH with atypia (also referred to as endometrial intraepithelial neoplasia [EIN]). Re: Disordered Proliferative Endometrium. Dr R. The functional layer thickens and then is shed during menstruation in humans and some other mammals, including apes, Old World. In the endometrial carcinoma, the staining signal was. If the biopsy was done in the first half of the cycle, the endometrium is expected to be in proliferative phase. Personal hx colorectal cancer Endometrial polyp Morbid obesity Presence of one or more factors, increases risk by 8 times. I am postmenopausal with uterine bleeding. SEE COMMENT. is this something t?" Answered by Dr. 2 vs 64. Disordered proliferation of endometrium just means that you have hormonal imbalance. Proliferative endometrium(15%) and secretory endometrium (5%) were identified in the postmenopausal women which is a comparable finding to other studies that reported a proliferative endometrium. 3 Metaplasia in the endometrium can occur in both the epithelium and rarely the stroma. Learn how we can help. X. The impact of the endometrial proliferative phase on human embryo implantation remains unclear, but deserves further attention, especially since in luteal phase endometrial biopsies, a transcriptional signature predictive for repeated implantation failure has been associated with reduced cell proliferation, possibly indicating proliferative. Learn how we can help. Dr R. proliferative endometrium: Endometrial hypertrophy due to estrogen stimulation during the preovulatory phase of the menstrual cycle. What does proliferative endometrium mean? Proliferative endometrium is a term pathologists use to describe the changes seen in the endometrium during the. 3,246 satisfied customers. 1646 postmenopausal women aged 55-96 (mean 64. 5% of women with abnormal uterine bleeding had proliferative or secretory endometrium. received endo biopsy result of secretory, focally inactive endometrium, neg for hyperplasia and malignancy. Endometrium biopsy: blood and weakly proliferative phase endometrium with glandular and stromal breakdown. No evidence of endometrium or malignancy. A member asked:. Introduction. My pathology report final diagnosis are as follows: Endometrium biopsy: blood and weakly proliferative phase endometrium with glandular and stromal breakdown. FRAGMENTS OF BENIGN ENDOCERVICALTISSUE. People who have atypical endometrial hyperplasia have a higher risk of developing uterine cancer. For example, the endometrium in most term foetuses and neonates is only weakly proliferative, despite prolonged exposure to very high concentrations of unbound estrogens and progesterone in utero. Among those women, 278 had a proliferative endometrium, and 684 had an atrophic endometrium. Conclusion One in six postmenopausal women who underwent endometrial sampling had proliferative endometrium. 5% of ospemifene. Proliferative endometrium isn’t a symptom or condition. Introduction. Diagnosis: Diagnosis: Fragments of weakly proliferative/inactive endometrium. Biopsy was done because I had a day of spotting 17 months. 81, p < 0. Endometrial hyperplasia is a condition of the female reproductive system. The findings in endometrial biopsies taken for abnormal uterine bleeding can show a wide range of appearances that reflect the cyclical changes in the endometrium in women during their reproductive years; accordingly, the histopathological diagnosis provides a description of the features observed microscopically (e. Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. Proliferative endometrium is a very common non-cancerous change that develops in the tissue lining the inside of the uterus. Ciliated cell changes (tubal metaplasia) is an early change. Prolonged exposure to progesterone induces a rounded cell characterized. A repeat "d&c after ablation " is usually not going to produce different results. Atrophic endometrial cells, on the other hand, are smaller and more cuboidal than proliferative endometrium. (female) Join Date: Nov 2007. . It refers toAn endometrial polyp was found in 86. Adenofibromas most commonly occur in postmenopausal women but the age range is wide. There was one case who was a 75-years-old woman presenting with both deep infiltrating endometriosis in bladder and small bowel and adenomyosis lesions, but her endometrium was weakly proliferative. . It can be healthy or disordered depending on the rate of cell growth and shedding. What is the meaning of proliferative endometrium? The proliferative endometrium stage is also called the follicular phase. In one study, follow-up outcomes of "gland-crowding" reports show 77% benign lesions (proliferative endometrium, secretory endometrium, endometrial polyp, etc. Screening for endocervical or endometrial cancer. DIAGNOSTIC APPROACH. - Negative for. read more Estrogen only: weakly to markedly proliferative endometrium, stromal breakdown, squamous morules Progestogen only: scant literature, secretory pattern (mildly tortuous glands with basal nuclei and scant luminal secretions) not always present Combined: Sequential: Weakly proliferative (small tubular glands with occasional mitoses) Endometrial Hyperplasia; An Update on Human Papillomavirus Vaccination in the United States; Effect of Second-Stage Pushing Timing on Postpartum Pelvic Floor Morbidity: A Randomized Controlled Trial; Permanent Compared With Absorbable Suture in Apical Prolapse Surgery: A Systematic Review and Meta-analysis Endometrial cancer is a common gynecological malignancy that can affect the uterus and other organs. 5. 5 to 7–8 mm during the mid-proliferative phase ( 17 ). • 01-2021 Vaginal Ultrasound: Showed 3 fibroids, endometrium lining 8. Relatively normal gland to stroma ratio (glands occupy < 50% of the. ENDOMETRIAL. 72 mm w/ polyp. A weakly proliferative endometrium with focal stromal breakdown typically indicates that the endometrial lining of the uterus is not thickening as it should during the menstrual cycle. The term describes healthy reproductive cell activity. Adenofibroma. The prevalence of endometriosis in reproductive-aged women is 2% to 10%, while in those who have been through menopause, the prevalence is an estimated 2. The metaplasia doesn't mean anything significant, and the glandular and stromal breakdown is often seen when there has been bleeding. Of the 71,579 consecutive gynecological pathology reports, 206 (0. No apparent endometrial hyperplasia was seen. The significance of the findings is that the metaplasia may present. Learn how we can help. 5. g. My interpretation is that the pathologist saw fragments of endometrium in the proliferative phase, in contrast to the secretory phase. 5%) showed abnormal secretory endometrium, three (2%) disordered proliferative endometrium and 20 (14. See also: endometriumPMID: 12611094. The mean age at which the patients were. what does that mean? 1 doctor. 19,20 Early diagnosis of endometrial cancer types can help to save lives of the patients, and studies such as ours demonstrating the performance of weakly supervised learning methods on real-world data are key to. Endometriosis is a condition in which cells similar to the lining of the uterus, or endometrium, grow outside the uterus. 00 is a billable/specific ICD-10-CM code that can be used to indicate a diagnosis for reimbursement purposes. Hysteroscopy is the gold standard to evaluate the endometrial cavity. Microscopic findings. New blood vessels develop and the endometrial glands become bigger in size. Adenofibroma. 10170. Endometriosis. 9 and 12. 5 years; P<. -- abundant neutrophils and blood. 8 became effective on October 1, 2023. -- balls of condensed endometrial stroma. Proliferative activity is relatively common in postmenopausal women ~25%. In CPE, there are no specific clinical features that correlate with the intensity of pathologic findings; the most specific histologic feature is the presence of plasma cells, and it is predominantly identified in weakly proliferative endometrium. Early detection and accurate diagnosis of these lesions and its precursor by endometrial cytology is now accepted in Japan and regarded as an effective primary method of evaluating endometrial pathology (atypical hyperplasia or carcinoma. Adenofibromas most commonly occur in postmenopausal women, but the age range is wide. The polyp is made up of an increased number of otherwise normal-appearing endometrial glands and stroma. Atrophic endometrium, also inactive endometrium, is the normal finding in postmenopausal women. Endometrial polyps are common and usually benign. leiomyoma, other polypoid masses. 0–3. 9% had other (various types of polyps). 78% cases) and. 9% Secretory Endometrium 151 14. 1 Patients often. Normal proliferative endometrium contains glands that are regularly spaced and that lie within stroma at a gland: stroma ratio of 1 to 1. Dilated glands usually with irregular shape (branched, convoluted, scalloped outer contours) > 10% of overall glands. 5. The clinical significance of EH lies in the associated risk of progression to endometrioid endometrial cancer (EC) and ‘atypical’ forms of EH are regarded as premalignant lesions. Non-physiological changes are referred to by some as pseudodecidualization or pseudodecidualized endometrium. Endometrial cancer is one of the most common types of gynecological cancer among women around the world. Endometrium at menopause is inactive and free of cyclical changes that are characteristics of the reproductive age. The endometrial. Wendy Askew answered. Most endometrial carcinomas maintain endometrioid differentiation; these also can contain areas of mucinous or squamous differentiation. 5% of women with abnormal uterine bleeding had proliferative or secretory endometrium. Results: All postmenopausal endometria were atrophic, but only 42 were inactive; of the remaining samples, 22 were weakly proliferative and 20 were mixed active and inactive. 2023 Feb 1;141 (2):265-267. Though there is a wealth of research into understanding the endometrial mechanisms involved in the implantation event, far less is known about the tissue’s regenerative properties, akin to. isnt the first part contradictory of each other or is everything normal?" Answered by Dr. . A: Low power view shows many morule formations in the endometrium. 7% cases and weakly proliferative endometrium in 34. 2; median, 2. Endometrial metaplasias and changes (EMCs) are conditions frequently overlooked and misdiagnosed. LM. Re: What is weakly proliferative endometrium. Women with a proliferative endometrium were younger (61. Demosthenes, MD. 8% of hysteroscopies and in 56. 0001). 451 views Answered >2 years ago. IHC was done using syndecan-1. Postmenopausal bleeding. The significance of the findings is that the metaplasia may present an. It is also the early proliferative phase and hence, a mixture of changes associated with menses and the early proliferative endometrium is seen . "what does it mean? inactive endometrium with focal tubal metaplasia? benign endometrial polyp. Contrary to endometrial hyperplasia, proliferative endometrium has not been associated with the risk of endometrial cancer. 2. In the present pictorial review, we briefly discuss the various morphologic. What is an endometrial polyp? An endometrial polyp is a non-cancerous growth found on the inside of the uterus. What does disordered proliferative endometrium mean? Disordered proliferative endometrium is a non-cancerous change that develops in the endometrium, a thin layer of tissue that lines the inside of the uterus. 1646 postmenopausal women aged 55-96 (mean 64. Endometrial Polyp - Fragments of weakly proliferative/ inactive endometrium. Physician. It is diagnosed by a pathologist on examination of endometrial tissue under a microscope. that is what weakly proliferative endometrium means. In one study, follow-up outcomes of "gland-crowding" reports show 77% benign lesions (proliferative endometrium, secretory endometrium, endometrial polyp, etc. comment: sections show rare strips of inactive glandular epithelium? 2 doctor answers • 2 doctors weighed in. What does this test result mean. Created for people with ongoing healthcare needs but benefits everyone. Endometrial receptivity describes the intricate process undertaken by the uterine lining to prepare for the implantation of an embryo. Normal: This is a normal thickening of the female sexual mucous and often indicates a fertime time of the month. Epub 2023 Jan 4. Prognosis. Estrogen only: weakly to markedly proliferative endometrium, stromal breakdown, squamous morules Progestogen only: scant. The term describes healthy reproductive cell activity. Read More. Results: After intervention in letrozole group, response to treatment was seen in 93% cases (including endometrial atrophy in 58. thank you endometrium, biopsy: -glandular and stromal breakdown, consistent with bleeding changes -negative for atypia or malignancy?. Proliferative endometrium indicates the follicular phase; whereas, secretory endometrium indicates luteal phase. Risk factors for developing endometrial cancer after benign sampling Factors independently associated with subsequent endometrial cancer. Endometriosis can affect women of any age, including teenagers. No worries, I know what you mean for sure. Proliferative activity is relatively common in postmenopausal women ~25%. 0–3. TABLE 1: 2012 Summary of Physician Office Endometrial Biopsy Specimens Diagnosis Number of Cases Percentage of Cases Proliferative Endometrium 239 23. It is also simply known as endometrial polyp which is a somewhat ambiguous descriptor as not all endometrial polyps are benign. 5 percent) Carcinoma (6. MD. In the past, the terms “adenomatous hyperplasia” and “atypical hyperplasia” were used to denote proliferative lesions of the endometrium with varying degrees of architectural complexity and cytologic atypia [15, 32, 37, 70, 93]. The endometrium from the uterine body and fundus is generally fairly uniform from one area to another. No cancer: Depending on the time of your menstrual cycle, it is a normal finding. Glands. What. DIAGNOSTIC APPROACH. 09–7. If left untreated, disordered proliferative endometrium can change into another non-cancerous condition called. These can lead to abnormal bleeding. Read More. The aim of this review is to update current issues and provide a classification with a practical clinicopathological approach. The main purpose of the endometrium is to provide an attachment site and a source of nourishment to an early embryo. Approximately 20% of postmenopausal patients have endometrial pathology. Many people find relief through progestin hormone treatments. 7% cases and weakly proliferative endometrium in 34. What do these results mean: ENDOMETRIAL BIOPSY: WEAKLY PROLIFERATIVE ENDOMETRIUM. We performed p16 immunostaining on 35 normal endometrial specimens and 32 EPs, six of which were associated with tamoxifen therapy. More African American women had a. Dr. Endometrial hyperplasia without atypia (as in the 2020 WHO classification) is defined as the proliferation of endometrial glands of irregular size and shape without significant cytological atypia. (2) Atrophic/weakly proliferative endometria were defined by the following criteria: (a) a shallow endometrium 2. Images of. endometrium, biopsy: - consistent with menstrual endometrium: -- stripped weakly proliferative endometrial glands. Objective In the last two decades, many reports demonstrated the unreliability of endometrial biopsy pathology showing an AH (atypical hyperplasia) to exclude a synchronous EEC (endometrioid endometrial carcinoma), with an underestimation of EEC in up to 50% of women. This is done to evaluate infertility or dysmenorrhea. Endometriosis often involves the pelvic tissue and can envelop the ovaries and fallopian tubes. The pathology breakdown showed: AE. 3–10% of endometrial biopsies are said to show histologic evidence of chronic endometritis. 0001). atrophy, endometrial hyperplasia, endometrial carcinoma, other gynecologic cancers. 3–10% of endometrial biopsies are said to show histologic evidence of chronic endometritis. Abstract. I had an endometrial biopsy 10 days ago and just received the results in the mail. Created for people with ongoing healthcare needs but. In contrast, the non-neoplastic component of 43 of the 50 endometrial adenocarcinomas examined was of the active form; four specimens were of the pure and 39 of the mixed. In this phase, tubular glands with columnar cells and surrounding dense stroma are proliferating to build up the endometrium following shedding with previous. Endometritis is inflammation of the endometrium (the inner lining of your uterus) due to infection. Thank. Discussion 3. -- abundant neutrophils and blood. Endometrial polyps are benign in nature and affect both reproductive age and postmenopausal women. The term proliferative endometrium refers to the state of the endometrial layer while it grows. Learn about the causes, symptoms,. The oral contraceptive pill is dealt with in the article oral contraceptive pill . Endometrial polyps are common and usually benign. Medical Director. Normal: Your endometrial lining was in the proliferative phase of the menstrual cycle. Personal hx colorectal cancer Endometrial polyp Morbid obesity Presence of one or more factors, increases risk by 8 times. The endometrial. Metaplasia in Endometrium is diagnosed by a pathologist on examination of. Compact. Weakly proliferative endometrium Normal proliferative endometrium Disordered proliferative Endometrial hyperplasia Asynchronously developed endometrium. Endometrial hyperplasia is a condition that causes abnormal uterine bleeding. - Negative for polyp, hyperplasia, atypia or. 1 To fulfil this latter role, the endometrium is unique in that it undergoes cyclical epithelial and stromal morphogenesis during the reproductive years. The tumour is, on the whole, the commonest gynaecological malignancy in the industrialised world,1–3 comprising 4% of all cancers in women, and a lifetime risk of 2–3%. A hysterectomy makes it impossible for you to become pregnant in the future. Thank. 4% Disordered Proliferative Endometrium 82 7. Disordered proliferative endometrium accounted for 5. Menstrual cycles (amount of time between periods) that are shorter than 21 days. Not having a period (pre-menopause)The degree of proliferative activity can usually be assessed by the mitotic activity in both the glandular epithelium and the stroma. Early age at marriage and early sterilization also play a role. MD. Papillary Proliferation Metaplasia in Endometrium is a type of metaplasia noted in the uterine corpus. . g. An “insufficient” EMB result should always be viewed cautiously, especially in the setting of persistent postmenopausal bleeding. Obstetrics and Gynecology 32 years experience. At least she chatted to you as much as possible about the results. 0% Exogenous. Endometrial hyperplasia (EH) is a proliferation of endometrial glands which is typically categorized into two groups: EH without atypia (usually not neoplastic) and EH with atypia (neoplastic; also referred to as endometrial intraepithelial neoplasia [EIN]). Contexts. Frequently, in histological samples of EGBD, metaplastic changes occur also in the endometrial surface epithelium (Figs. Female Genital Pathology. Endometrial hyperplasia (EH) is a spectrum of morphological changes ranging from a slightly disordered pattern seen in the late proliferative phase of the menstrual cycle to the irregular proliferation of the endometrial glands with an increase in gland-to-stroma ratio leading to thickening of the endometrium []. what does that mean?1. However, it can also be seen with pre-cancerous or cancerous diseases and your doctor may suggest a biopsy of the endometrium to look for more serious conditions. This test is also used to identify uterine infections, such as endometritis . 11. Asherman’s syndrome ( uterine adhesions) Endometrial cancer. We distinguished basalis endometrium from functionalis endometrium by defined histological criteria as described previously by Hendrickson et al. The endometrium becomes thicker leading up to ovulation to provide a suitable environment for a fertilized egg to grow inside the uterus. 5 cm. Endometrial Changes During the Menopause An endometrium that atrophies and loses it functional layer, with endometrial stroma that becomes fibrous andThe primary symptom of endometrial hyperplasia is abnormal menstrual bleeding. Harold Fields answered. In the past, the terms “adenomatous hyperplasia” and “atypical hyperplasia” were used to denote proliferative lesions of the endometrium with varying degrees of architectural complexity and cytologic atypia [15, 32, 37, 70, 93]. Endometrial cancer is a type of cancer that begins as a growth of cells in the uterus. What does weakly proliferative endometrium mean. However, adenomyosis can cause: Heavy or prolonged menstrual bleeding. No polarizing material was present in the granulomas, and. -. The spectrum of. This diagnosis means that after examining your tissue sample under the microscope, your pathologist saw irregular and dilated endometrial glands in the proliferative phase (growing phase). In this study we correlate the # of plasma cells by H&E to the # of plasma cells by CD138 IHC in endometrial biopsies. Smith et al 16 reported that 348 of 1832 women (19%) with PMB had “functional endometria” in their initial evaluation of PMB. They described functional endometrium as being “weakly proliferative” or “weakly. 3% had proliferative pattern (disorder type) tissue; 0. Proliferative endometrium suggests active estradiol secretion, akin to that seen in the proliferative phase of the menstrual cycle, and is not a form of EH. Recognition as an Endometrial Stromal Neoplasm (Biopsy/Curettage Specimen) The first clue that a biopsy/curettage specimen harbors an endometrial stromal neoplasm is the finding of multiple. Biopsy proliferative phase endometrium with disorder features and focal stromal breakdown. endometrium, biopsy: - consistent with menstrual phase endometrium: -- weakly proliferative endometrial glands with neutrophils and apoptosis. Definition / general. Atrophic/weakly proliferative endometria were defined by the following criteria: (a) a shallow endometrium 2. 6k views Reviewed Dec 27, 2022. Read More. The Proliferative Phase. 2). 001). Proliferative endometrium is part of the female reproductive process. These sound like the results from an endometrial biopsy - basically, when your doctor takes a clipping or scraping from inside the uterus and sends it off to a pathologist to be examined. This refers to: Build up of the uterine lining, as would happen in the cycle prior to ovulation (egg release) to prepare for implantation of the fertilized egg. Van den Bosch et al 11 found that 14. The stromal cells are arranged in a compact manner. Doctor of Medicine. Weakly proliferative endometrium means that the Prempro is causing some buildup of your uterine lining, which has led to the bleeding. Proliferative endometrium describes the 'stage' of the endometrium when it was biopsied. Instead, DPE is characterized by irregularly shaped, cystically dilated glands producing a disordered arrangement. The presence of weakly proliferative endometrium in high risk women with PMB for endometrial adendocarcinoma hysterectomy may be indicated especially if follow-up of the patient is difficult. Endometrial carcinoma is the most common invasive neoplasm of the female reproductive tract. read moreSpecimens A. ), 19% premalignant lesions, and. Endometrial hyperplasia is a condition that causes abnormal uterine bleeding. However, certain conditions can develop if the. After menstruation, proliferative changes occur during a period of tissue regeneration. Created for people with ongoing healthcare needs but benefits everyone. satisfied customers. 25% of patients with endometrial cancer had a previous benign EMB/D&C. May be day 5-13 - if the menstruation is not included. Therefore, it is necessary to know the phase of the menstrual cycle and the endometrial biopsy volume to. Disordered proliferative endometrium. However, in some instances, they cause pain, irregular bleeding, or infertility. The two biopsies showed a normal proliferative pattern endometrium. Endometrium - EMC - Fragments of weakly proliferative/inactive endometrium. Proliferative endometrium is a noncancerous (benign) and normal cause of thickening seen on an ultrasound. Early proliferative (day 4-7 ) Straight short glands, thin epithelium. Endometrial polyps. Keywords: endometrium, atrophic, inactive, weakly proliferative, endometrial adenocarcinoma. Does proliferative endometrium mean cancer? No. Read More. Glands are. Endometrium at menopause is inactive and free of cyclical changes that are characteristics of the reproductive age. Indeed polyps, adenomyosis, and leiomyomas have all been associated with an increased likelihood of abnormal endometrial molecular expressions thought to impair implantation and early embryo development. Endocervical/tissue: A "pap smear" may contain some tissue from the canal leading to the womb (endocervical canal) which grows out over the surface of the cervix and is se. They described functional endometrium as being “weakly proliferative” or “weakly. Conditions that involve the endometrium and may impact fertility include: Adenomyosis. The histologic effect depends on the hormone, the potency, dosage, and the host receptor status. The last menstrual period should be correlated with EMB results. 3k views Reviewed >2 years ago. Endometrial tubal metaplasia (ETM) is mostly described in conjunction with unopposed estrogen levels, and its association with endometrial hyperplasia and endometrial carcinoma (EC) is striking. Read More. It is diagnosed by a pathologist on examination of endometrial tissue under a microscope. Signs and symptoms of uterine polyps include: Vaginal bleeding after menopause. Open in a separate window. EH, especially EH with atypia, is of clinical significance because it may progress to. focal mucinous metaplasia. Endometrium biopsy: blood and weakly proliferative phase endometrium with glandular and stromal breakdown. Ed Friedlander and 4 doctors agree.